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. Within the load situation a sample loop—which is out there in many different measurements starting from 0.5 ?L to 5 mL—is isolated with the mobile phase and open up for the environment. The sample loop is loaded employing a syringe by using a ability several moments that in the sample loop, with surplus sample exiting in the squander line.Ion
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This reactive epoxide intermediate may react with amino acid residues of the CYP enzyme to kind drug-CYP (drug-protein) adducts (Plan 6, pathway C). The formation of your drug-CYP adducts might or might not reveal a time-dependent inactivation in the catalytic action of this CYP enzyme, depending on the covalent binding of the reactive intermediate